| GMT-6 | Wed May 5, 2021 |
|---|---|
| 6:15 | Rays(12) v Mariners(13) |
| 6:15 | Giants(6) v Reds(23) |
| 7:30 | Rockies(17) v Padres(7) |
| 7:30 | Royals(16) v Tigers(11) |
| 7:30 | Athletics(14) v Cubs(15) |
| 8:45 | White Sox(20) v Diamondbacks(15) |
| 8:45 | Orioles(22) v Brewers(8) |
| 8:45 | Cardinals(15) v Yankees(16) |
Legend:
