| GMT-6 | Wed June 16, 2021 |
|---|---|
| 6:15 | Tigers(16) v Royals(17) |
| 6:15 | Orioles(14) v White Sox(16) |
| 6:15 | Brewers(23) v Giants(11) |
| 7:30 | Mariners(19) v Rays(6) |
| 7:30 | Rockies(31) v Reds(13) |
| 8:45 | Cubs(19) v Padres(12) |
| 8:45 | Diamondbacks(20) v Cardinals(4) |
| 8:45 | Yankees(23) v Athletics(19) |
Legend:
