| GMT-6 | Wed September 15, 2021 |
|---|---|
| 6:15 | Brewers(11) v Yankees(15) |
| 6:15 | Rockies(21) v Tigers(28) |
| 7:30 | Diamondbacks(17) v White Sox(18) |
| 7:30 | Padres(18) v Reds(19) |
| 7:30 | Giants(14) v Royals(21) |
| 8:45 | Mariners(23) v Athletics(13) |
| 8:45 | Cubs(11) v Cardinals(15) |
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