| GMT-6 | Wed September 22, 2021 |
|---|---|
| 6:15 | Cardinals(21) v Tigers(7) |
| 6:15 | Cubs(17) v Reds(10) |
| 7:30 | Brewers(15) v Mariners(16) |
| 7:30 | Athletics(14) v Rockies(13) |
| 7:30 | White Sox(11) v Yankees(20) |
| 8:45 | Giants(19) v Diamondbacks(20) |
| 8:45 | Padres(11) v Royals(18) |
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