| GMT-6 | Mon September 27, 2021 |
|---|---|
| 6:15 | Padres(10) v Cubs(20) |
| 6:15 | Royals(4) v Yankees(13) |
| 7:30 | White Sox(14) v Mariners(15) |
| 7:30 | Brewers(20) v Rockies(19) |
| 7:30 | Diamondbacks(18) v Giants(16) |
| 8:45 | Cardinals(28) v Reds(14) |
| 8:45 | Tigers(13) v Athletics(21) |
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