| GMT-6 | Mon April 25, 2022 |
|---|---|
| 6:15 | White Sox(26) v Yankees(19) |
| 6:15 | Cubs(15) v Giants(12) |
| 7:30 | Orioles(15) v Royals(11) |
| 7:30 | Tigers(19) v Rays(18) |
| 7:30 | Padres(21) v Diamondbacks(20) |
| 8:45 | Cardinals(26) v Brewers(27) |
| 8:45 | Reds(19) v Rockies(20) |
| 8:45 | Mariners(21) v Athletics(17) |
Legend:
