| GMT-6 | Wed April 27, 2022 |
|---|---|
| 6:15 | Athletics(10) v Tigers(18) |
| 6:15 | Brewers(18) v Padres(9) |
| 7:30 | Rockies(17) v Cubs(18) |
| 7:30 | Yankees(14) v Orioles(16) |
| 7:30 | Giants(22) v Cardinals(12) |
| 8:45 | Diamondbacks(19) v Reds(20) |
| 8:45 | Royals(16) v Mariners(5) |
| 8:45 | Rays(17) v White Sox(24) |
Legend:
