| GMT-6 | Wed May 4, 2022 |
|---|---|
| 6:15 | Cubs(16) v Royals(10) |
| 6:15 | Reds(21) v Tigers(14) |
| 7:30 | Yankees(27) v Padres(17) |
| 7:30 | Rockies(23) v Mariners(8) |
| 7:30 | Diamondbacks(13) v Athletics(14) |
| 8:45 | Giants(13) v White Sox(14) |
| 8:45 | Cardinals(23) v Rays(24) |
| 8:45 | Orioles(15) v Brewers(16) |
Legend:
